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Platelet Rich Plasma PRP

What is PRP?

Platelet-rich plasma (PRP) is a therapy that involves the injection of a concentrated solution of platelets and plasma into the skin or scalp. The concentration of platelets is typically 2-8X whole blood native concentration. Platelets are a type of blood cell that play a crucial role in the healing process. They contain growth factors and other signaling molecules that stimulate the repair of damaged tissue and promote new cell growth. Plasma is the clear, straw-colored fluid portion of the blood that contains proteins, electrolytes, and other substances. PRP has been used since the mid-90s and is FDA cleared as a class II medical device.

Mechanism of action

The mechanism of action of PRP is not fully understood, but it is thought to work by providing a burst of growth factors and other signaling molecules to the area being treated. These growth factors stimulate the production of new collagen, elastin, and other components of the extracellular matrix, which in turn helps to repair damaged tissue and promote the formation of new blood vessels. Some growth factors thought to be involved are as follows:

  • EGF (Epidermal Growth Factor) – promotion of epithelial cell growth, angiogenesis, promotion of wound healing

  • FGF (Fibroblast Growth Factor) – tissue repair, cell growth, collagen production

  • PDGF (Platelet Derived Growth Factor) – cell growth, new generation and repair of blood vessels, collagen production

  • VEGF (Vascular Endothelial Growth Factor) – growth and new generation of vascular endothelial cells

  • TGF-B (Transforming Growth Factor Beta1) – growth of epithelial cells, endothelial cells , promotion of wound healing

  • KGR (Keratinocyte Growth Factor) – growth and new generation of keratinocyte

Benefits of PRP

PRP has a number of potential benefits, particularly in the treatment of androgenetic alopecia (AGA), also known as male or female pattern baldness. In this condition, hair follicles shrink and produce thinner, shorter hairs over time, leading to hair loss. PRP injections may help to stimulate the growth of new hair and improve the appearance of thinning hair.

Key benefits include:

  • Promotion of vascularization

  • Promotion of angiogenesis

  • Triggers anagen entry

  • Extends anagen duration

  • Inflammation/oxidative stress reduction

  • Triggers hair stem cell regeneration

PRP may also be used in combination with hair transplantation to improve the success of the procedure. Some studies have shown that PRP can improve the survival rate of transplanted hair follicles, leading to better results and more natural-looking hair.

  • Key benefits of PRP in hair transplantation:

  • “Jump starts” healing process

  • Provides provisional matrix or scaffold for healing

  • Improves hemostasis

  • Post surgical implications

  • Anti-inflammatory properties

  • Anti-microbial properties

Isolation & injection methods

There are several methods for isolating and injecting PRP. One common method is to draw a small amount of blood from the patient, then spin it in a centrifuge to separate the platelets and plasma from the red and white blood cells. The resulting PRP solution is then injected into the treatment area using a fine needle.

Combination therapy

PRP may be used as a standalone therapy or in combination with other treatments, such as microneedling or topical medications. However, there is some controversy over the effectiveness of PRP, as the results of studies have been mixed and more research is needed to fully understand its mechanisms of action.

Complications

There are also some potential complications and contraindications to PRP treatment. People who are taking blood thinners or have certain blood disorders may not be good candidates for PRP. In addition, there is a risk of infection and bleeding at the injection site, as well as the possibility of allergic reactions to the components of the PRP solution. It is important to discuss the potential risks and benefits of PRP with a healthcare provider before undergoing treatment.

Relative contraindications

  • Patients with active infection in scalp

  • History of severe viral infection

  • Diabetes

  • Clotting disorders

  • Blood-thinning medications

  • Immunosuppressive drugs, i.e. cyclosporine

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